View Dr. Amali Samarasinghe’s publications on NCBI My Bibliography
- Best Practices in the Development and Use of Experimental Models of Bacterial Pneumonia: An Official American Thoracic Society Workshop Report. Am J Respir Cell Mol Biol. 2025 Aug;73(2):178-199. doi: 10.1165/rcmb.2025-0322ST. PubMed PMID: 40748059; PubMed Central PMCID: PMC12334885.
- Roland LT, Damask C, Luong AU, Azar A, Ebert CS Jr, Edwards T, Cahill KN, Cho DY, Corry D, Croston TL, Freeman AF, Javer A, Khoury P, Kim J, Koval M, McCoul ED, Mims JW, Peters A, Piccirillo JF, Ramonell RP, Samarasinghe A, Schleimer RP, Smith-Davidson P, Spec A, Wechsler ME, Wise SK, Levy JM. Allergic Fungal Rhinosinusitis Diagnosis, Management, Associated Conditions, Pathophysiology, and Future Directions: Summary of a Multidisciplinary Workshop. Int Forum Allergy Rhinol. 2025 Jun;15(6):626-641. doi: 10.1002/alr.23582. Epub 2025 May 1. Review. PubMed PMID: 40310935.
- Gazzinelli-Guimaraes PH, Jones SM, Voehringer D, Mayer-Barber KD, Samarasinghe AE. Eosinophils as modulators of host defense during parasitic, fungal, bacterial, and viral infections. J Leukoc Biol. 2024 Nov 27;116(6):1301-1323. doi: 10.1093/jleuko/qiae173. Review. PubMed PMID: 39136237.
- Auld SC, Sheshadri A, Alexander-Brett J, Aschner Y, Barczak AK, Basil MC, Cohen KA, Dela Cruz C, McGroder C, Restrepo MI, Ridge KM, Schnapp LM, Traber K, Wunderink RG, Zhang D, Ziady A, Attia EF, Carter J, Chalmers JD, Crothers K, Feldman C, Jones BE, Kaminski N, Keane J, Lewinsohn D, Metersky M, Mizgerd JP, Morris A, Ramirez J, Samarasinghe AE, Staitieh BS, Stek C, Sun J, Evans SE. Postinfectious Pulmonary Complications: Establishing Research Priorities to Advance the Field: An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc. 2024 Sep;21(9):1219-1237. doi: 10.1513/AnnalsATS.202406-651ST. Review. PubMed PMID: 39051991.
- Sharma A, Samarasinghe AE. “It’s A Trap!”: Eosinophils Caught Between Pro- and Anti-inflammatory Responses. Am J Respir Cell Mol Biol. 2024 Aug 13;72(1):3-5. doi: 10.1165/rcmb.2024-0325ED. [Epub ahead of print] PubMed PMID: 39137338; PubMed Central PMCID: PMC11707663.
- Shoraka S, Samarasinghe AE, Ghaemi A, Mohebbi SR. Host mitochondria: more than an organelle in SARS-CoV-2 infection. Front Cell Infect Microbiol. 2023;13:1228275. doi: 10.3389/fcimb.2023.1228275. eCollection 2023. Review. PubMed PMID: 37692170; PubMed Central PMCID: PMC10485703.
- Taylor MK, Williams EP, Xue Y, Jenjaroenpun P, Wongsurawat T, Smith AP, Smith AM, Parvathareddy J, Kong Y, Vogel P, Cao X, Reichard W, Spruill-Harrell B, Samarasinghe AE, Nookaew I, Fitzpatrick EA, Smith MD, Aranha M, Smith JC, Jonsson CB. Dissecting Phenotype from Genotype with Clinical Isolates of SARS-CoV-2 First Wave Variants. Viruses. 2023 Feb 23;15(3). doi: 10.3390/v15030611. PubMed PMID: 36992320; PubMed Central PMCID: PMC10059853.
- Marathe SJ, Snider MA, Flores-Torres AS, Dubin PJ, Samarasinghe AE. Human matters in asthma: Considering the microbiome in pulmonary health. Front Pharmacol. 2022;13:1020133. doi: 10.3389/fphar.2022.1020133. eCollection 2022. Review. PubMed PMID: 36532717; PubMed Central PMCID: PMC9755222.
- Flores-Torres AS, Samarasinghe AE. Impact of Therapeutics on Unified Immunity During Allergic Asthma and Respiratory Infections. Front Allergy. 2022;3:852067. doi: 10.3389/falgy.2022.852067. eCollection 2022. Review. PubMed PMID: 35386652; PubMed Central PMCID: PMC8974821.
- Bonjour K, Palazzi C, Silva TP, Malta KK, Neves VH, Oliveira-Barros EG, Neves I, Kersten VA, Fortuna BT, Samarasinghe AE, Weller PF, Bandeira-Melo C, Melo RCN. Mitochondrial Population in Mouse Eosinophils: Ultrastructural Dynamics in Cell Differentiation and Inflammatory Diseases. Front Cell Dev Biol. 2022;10:836755. doi: 10.3389/fcell.2022.836755. eCollection 2022. PubMed PMID: 35386204; PubMed Central PMCID: PMC8979069.
- Tiwary M, Samarasinghe AE. Initiation and Pathogenesis of Severe Asthma with Fungal Sensitization. Cells. 2021 Apr 15;10(4). doi: 10.3390/cells10040913. Review. PubMed PMID: 33921169; PubMed Central PMCID: PMC8071493.
- Tiwary M, Rooney RJ, Liedmann S, LeMessurier KS, Samarasinghe AE. Eosinophil Responses at the Airway Epithelial Barrier during the Early Phase of Influenza A Virus Infection in C57BL/6 Mice. Cells. 2021 Feb 27;10(3). doi: 10.3390/cells10030509. PubMed PMID: 33673645; PubMed Central PMCID: PMC7997358.
- Tiwary M, LeMessurier KS, Samarasinghe AE. Murine Models of Eosinophil Function in Fungal and Viral Infections. Methods Mol Biol. 2021;2241:99-112. doi: 10.1007/978-1-0716-1095-4_9. PubMed PMID: 33486731; PubMed Central PMCID: PMC8142467.
- Samarasinghe AE, Penkert RR, Hurwitz JL, Sealy RE, LeMessurier KS, Hammond C, Dubin PJ, Lew DB. Questioning Cause and Effect: Children with Severe Asthma Exhibit High Levels of Inflammatory Biomarkers Including Beta-Hexosaminidase, but Low Levels of Vitamin A and Immunoglobulins. Biomedicines. 2020 Oct 6;8(10). doi: 10.3390/biomedicines8100393. PubMed PMID: 33036262; PubMed Central PMCID: PMC7600116.
- LeMessurier KS, Rooney R, Ghoneim HE, Liu B, Li K, Smallwood HS, Samarasinghe AE. Influenza A virus directly modulates mouse eosinophil responses. J Leukoc Biol. 2020 Jul;108(1):151-168. doi: 10.1002/JLB.4MA0320-343R. Epub 2020 May 9. PubMed PMID: 32386457; PubMed Central PMCID: PMC7859173.
- LeMessurier KS, Tiwary M, Morin NP, Samarasinghe AE. Respiratory Barrier as a Safeguard and Regulator of Defense Against Influenza A Virus and Streptococcus pneumoniae. Front Immunol. 2020;11:3. doi: 10.3389/fimmu.2020.00003. eCollection 2020. Review. PubMed PMID: 32117216; PubMed Central PMCID: PMC7011736.
- Samarasinghe AE, Rosch JW. Convergence of Inflammatory Pathways in Allergic Asthma and Sickle Cell Disease. Front Immunol. 2019;10:3058. doi: 10.3389/fimmu.2019.03058. eCollection 2019. Review. PubMed PMID: 32038616; PubMed Central PMCID: PMC6992560.
- LeMessurier KS, Iverson AR, Chang TC, Palipane M, Vogel P, Rosch JW, Samarasinghe AE. Allergic inflammation alters the lung microbiome and hinders synergistic co-infection with H1N1 influenza virus and Streptococcus pneumoniae in C57BL/6 mice. Sci Rep. 2019 Dec 18;9(1):19360. doi: 10.1038/s41598-019-55712-8. PubMed PMID: 31852944; PubMed Central PMCID: PMC6920369.
- Lamichhane PP, Samarasinghe AE. The Role of Innate Leukocytes during Influenza Virus Infection. J Immunol Res. 2019;2019:8028725. doi: 10.1155/2019/8028725. eCollection 2019. Review. PubMed PMID: 31612153; PubMed Central PMCID: PMC6757286.
- LeMessurier KS, Samarasinghe AE. Eosinophils: Nemeses of Pulmonary Pathogens?. Curr Allergy Asthma Rep. 2019 Jun 19;19(8):36. doi: 10.1007/s11882-019-0867-1. Review. PubMed PMID: 31218528; PubMed Central PMCID: PMC6993982.
- Palipane M, Snyder JD, LeMessurier KS, Schofield AK, Woolard SN, Samarasinghe AE. Macrophage CD14 impacts immune defenses against influenza virus in allergic hosts. Microb Pathog. 2019 Feb;127:212-219. doi: 10.1016/j.micpath.2018.12.008. Epub 2018 Dec 5. PubMed PMID: 30529429; PubMed Central PMCID: PMC7872093.
- Veerapandian R, Snyder JD, Samarasinghe AE. Influenza in Asthmatics: For Better or for Worse?. Front Immunol. 2018;9:1843. doi: 10.3389/fimmu.2018.01843. eCollection 2018. Review. PubMed PMID: 30147697; PubMed Central PMCID: PMC6095982.
- Hatami E, Nagesh PKB, Chowdhury P, Chauhan SC, Jaggi M, Samarasinghe AE, Yallapu MM. Tannic Acid-Lung Fluid Assemblies Promote Interaction and Delivery of Drugs to Lung Cancer Cells. Pharmaceutics. 2018 Aug 1;10(3). doi: 10.3390/pharmaceutics10030111. PubMed PMID: 30071698; PubMed Central PMCID: PMC6161105.
- Armbruster-Lee J, Cavender CP, Lieberman JA, Samarasinghe AE. Understanding fibrosis in eosinophilic esophagitis: Are we there yet?. J Leukoc Biol. 2018 Jul;104(1):31-40. doi: 10.1002/JLB.5MR1017-395R. Epub 2018 Jan 29. Review. PubMed PMID: 29377264.
- LeMessurier KS, Palipane M, Tiwary M, Gavin B, Samarasinghe AE. Chronic features of allergic asthma are enhanced in the absence of resistin-like molecule-beta. Sci Rep. 2018 May 4;8(1):7061. doi: 10.1038/s41598-018-25321-y. PubMed PMID: 29728628; PubMed Central PMCID: PMC5935686.
- Lew DB, LeMessurier KS, Palipane M, Lin Y, Samarasinghe AE. Saccharomyces cerevisiae-Derived Mannan Does Not Alter Immune Responses to Aspergillus Allergens. Biomed Res Int. 2018;2018:3298378. doi: 10.1155/2018/3298378. eCollection 2018. PubMed PMID: 29511677; PubMed Central PMCID: PMC5817814.
- Doorley LA, LeMessurier KS, Iverson AR, Palipane M, Samarasinghe AE. Humoral immune responses during asthma and influenza co-morbidity in mice. Immunobiology. 2017 Dec;222(12):1064-1073. doi: 10.1016/j.imbio.2017.08.002. Epub 2017 Sep 7. PubMed PMID: 28889999; PubMed Central PMCID: PMC5650545.
- Lew DB, Michael CF, Overbeck T, Robinson WS, Rohman EL, Lehman JM, Patel JK, Eiseman B, LeMessurier KS, Samarasinghe AE, Gaber MW. Beneficial Effects of Prebiotic Saccharomyces cerevisiae Mannan on Allergic Asthma Mouse Models. J Immunol Res. 2017;2017:3432701. doi: 10.1155/2017/3432701. Epub 2017 Aug 1. PubMed PMID: 28835901; PubMed Central PMCID: PMC5556605.
- Michael CF, Waters CM, LeMessurier KS, Samarasinghe AE, Song CY, Malik KU, Lew DB. Airway Epithelial Repair by a Prebiotic Mannan Derived from Saccharomyces cerevisiae. J Immunol Res. 2017;2017:8903982. doi: 10.1155/2017/8903982. Epub 2017 Jul 9. PubMed PMID: 28770233; PubMed Central PMCID: PMC5523272.
- Apiwattanakul N, Palipane M, Samarasinghe AE. Immune responses to fungal aeroallergen in Heligmosomoides polygyrus-infected mice vary by age. Cell Immunol. 2017 Jul;317:26-36. doi: 10.1016/j.cellimm.2017.04.009. Epub 2017 Apr 27. PubMed PMID: 28476343.
- Samarasinghe AE, Melo RC, Duan S, LeMessurier KS, Liedmann S, Surman SL, Lee JJ, Hurwitz JL, Thomas PG, McCullers JA. Eosinophils Promote Antiviral Immunity in Mice Infected with Influenza A Virus. J Immunol. 2017 Apr 15;198(8):3214-3226. doi: 10.4049/jimmunol.1600787. Epub 2017 Mar 10. PubMed PMID: 28283567; PubMed Central PMCID: PMC5384374.
- LeMessurier KS, Lin Y, McCullers JA, Samarasinghe AE. Antimicrobial peptides alter early immune response to influenza A virus infection in C57BL/6 mice. Antiviral Res. 2016 Sep;133:208-17. doi: 10.1016/j.antiviral.2016.08.013. Epub 2016 Aug 13. PubMed PMID: 27531368; PubMed Central PMCID: PMC5903439.
- Samarasinghe A, Hoselton SA, Schuh JM, McCullers JA. Modeling Asthma and Influenza Co-morbidity in C57BL/6J Mice. Journal of Visualized Experiments. 2016 August. doi: 10.3791/53269.
- Hrincius ER, Liedmann S, Finkelstein D, Vogel P, Gansebom S, Samarasinghe AE, You D, Cormier SA, McCullers JA. Acute Lung Injury Results from Innate Sensing of Viruses by an ER Stress Pathway. Cell Rep. 2015 Jun 16;11(10):1591-603. doi: 10.1016/j.celrep.2015.05.012. Epub 2015 Jun 4. PubMed PMID: 26051937; PubMed Central PMCID: PMC4682876.
- Ghosh S, Samarasinghe AE, Hoselton SA, Dorsam GP, Schuh JM. Hyaluronan deposition and co-localization with inflammatory cells and collagen in a murine model of fungal allergic asthma. Inflamm Res. 2014 Jun;63(6):475-84. doi: 10.1007/s00011-014-0719-3. Epub 2014 Feb 12. PubMed PMID: 24519432; PubMed Central PMCID: PMC4020973.
- Samarasinghe AE, Woolard SN, Boyd KL, Hoselton SA, Schuh JM, McCullers JA. The immune profile associated with acute allergic asthma accelerates clearance of influenza virus. Immunol Cell Biol. 2014 May-Jun;92(5):449-59. doi: 10.1038/icb.2013.113. Epub 2014 Jan 28. PubMed PMID: 24469764; PubMed Central PMCID: PMC4037497.
- Samarasinghe AE, Hoselton SA, Schuh JM. A comparison between intratracheal and inhalation delivery of Aspergillus fumigatus conidia in the development of fungal allergic asthma in C57BL/6 mice. Fungal Biol. 2011 Jan;115(1):21-9. doi: 10.1016/j.funbio.2010.09.013. Epub 2010 Oct 8. PubMed PMID: 21215951; PubMed Central PMCID: PMC3053007.
- Samarasinghe AE, Hoselton SA, Schuh JM. The absence of VPAC2 leads to aberrant antibody production in Aspergillus fumigatus sensitized and challenged mice. Peptides. 2011 Jan;32(1):131-7. doi: 10.1016/j.peptides.2010.09.022. Epub 2010 Oct 13. PubMed PMID: 20923692; PubMed Central PMCID: PMC3299058.
- Hoselton SA, Samarasinghe AE, Seydel JM, Schuh JM. An inhalation model of airway allergic response to inhalation of environmental Aspergillus fumigatus conidia in sensitized BALB/c mice. Med Mycol. 2010 Dec;48(8):1056-65. doi: 10.3109/13693786.2010.485582. Epub 2010 May 20. PubMed PMID: 20482452; PubMed Central PMCID: PMC3113699.
- Samarasinghe AE, Hoselton SA, Schuh JM. Spatio-temporal localization of vasoactive intestinal peptide and neutral endopeptidase in allergic murine lungs. Regul Pept. 2010 Sep 24;164(2-3):151-7. doi: 10.1016/j.regpep.2010.05.017. Epub 2010 Jun 8. PubMed PMID: 20566347; PubMed Central PMCID: PMC2926301.
- Dorsam GP, Hoselton SA, Sandy AR, Samarasinghe AE, Vomhof-Dekrey EE, Dorsam ST, Schuh JM. Gene expression profiling and network analysis of peripheral blood monocytes in a chronic model of allergic asthma. Microbiol Immunol. 2010 Sep;54(9):558-63. doi: 10.1111/j.1348-0421.2010.00242.x. PubMed PMID: 20840155; PubMed Central PMCID: PMC3102558.
- Samarasinghe AE, Hoselton SA, Schuh JM. The absence of the VPAC(2) receptor does not protect mice from Aspergillus induced allergic asthma. Peptides. 2010 Jun;31(6):1068-75. doi: 10.1016/j.peptides.2010.03.001. Epub 2010 Mar 11. PubMed PMID: 20226823; PubMed Central PMCID: PMC2873113.
- Hoselton SA, Samarasinghe AE, Seydel JL, Serie KM, Schuh JM. Creation and characterization of an IgG1-type monoclonal antibody against intact Aspergillus fumigatus conidia. Hybridoma (Larchmt). 2007 Aug;26(4):251-4. doi: 10.1089/hyb.2007.002. PubMed PMID: 17725387.